Dietary Sesame Seed and Its Lignan, Sesamin, Increase Tocopherol and Phylloquinone Concentrations in Male Rats

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Sesame Seed Lignans Diversity, Human Metabolism and Bioactivities

Moazzami, A.A. 2006. Sesame Seed Lignans Diversity, Human Metabolism and Bioactivity. Doctor’s dissertation. ISSN 1652-6880, ISBN 91-576-7147-8 Sesame seed has been an important oilseed since ancient times. It contains 25% protein and 50% oil. Sesame seed possesses many health promoting effects, some of which have been attributed to a group of compounds called lignans (sesamin, sesamolin, sesam...

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Dietary Phytosterols Inhibit the Lipid Modulating Effects of Sesamin in Rats

The major lignan in the unsaponifiable fraction of sesame lipids, sesamin, is known to affect lipid metabolism. For example, sesamin inhibits the clearance of tocopherols, the activity of Δ5-desaturase during fatty acid metabolism, and reduces cholesterol absorption and biosynthesis. In order to study whether dietary phytosterols, which are known to reduce the absorption of lipid soluble dietar...

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The Sesame Lignan Sesamin Attenuates Vascular Permeability in Rats with Streptozotocin-Induced Diabetes: Involvement of Oxidative Stress

Background: Cardiovascular disorders are a major cause of morbidity and mortality in diabetic patients. Increased vascular permeability is a hallmark of diabetic vasculopathy, and the administration of natural products with antioxidant activity could restore vascular function. Objectives: In this study, the effect of chronic treatment with sesamin on vascular permeability in rats with streptozo...

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The mechanism underlying the synergetic hypocholesterolemic effect of sesamin and α-tocopherol in rats fed a high-cholesterol diet.

Sesamin is a major lignan in sesame seed. We confirmed that ingestion of sesamin and α-tocopherol synergistically reduced the concentration of blood cholesterol in rats given a high-cholesterol diet. To elucidate the molecular mechanism behind this effect, we analyzed the gene-expression profiles in rat liver after co-ingestion of sesamin and α-tocopherol. Six-week-old male Sprague-Dawley rats ...

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Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats.

Effects of sesamin and sesamolin (sesame lignans) on hepatic fatty acid metabolism were compared in rats. Rats were fed either a lignan-free diet, a diet containing 0.6 or 2 g/kg lignan (sesamin or sesamolin), or a diet containing both sesamin (1.4 g/kg) and sesamolin (0.6 g/kg) for 10 d. Sesamin and sesamolin dose-dependently increased the activity and mRNA abundance of various enzymes involve...

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ژورنال

عنوان ژورنال: The Journal of Nutrition

سال: 2013

ISSN: 1541-6100,0022-3166

DOI: 10.3945/jn.113.176636